Article
Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction.
Nature genetics - 1 May 2026
Cheng Fei-Fei, Liu Xiaoxi, Mi Hao, Wang Lizhong, Ma Ruilei, Guo Yazhou, Sidorenko Julia, Jiang Chen, Islam Tania, Meguro Akira, Hikino Keiko, Ishikawa Yuki, Tang Senwei, Li Teng, Chen Ruoyan, Wang Likun, Mägi Reedik, Metspalu Andres, Takeuchi Masaki, Mizuki Nobuhisa, Choquet Hélène, Jin Zi-Bing, Chen Gang, Zhou Kun, Terao Chikashi, Zeng Jian, Yang Jian
Abstract excerpt
Refractive errors (REs) affect over half of the global population, with consequences ranging from blurred vision to blindness. Here we conducted ancestry-stratified and cross-ancestry meta-analyses of genome-wide association studies for RE in people of European (n = 1,495,159), East Asian (n = 121,172) and African (n = 144,737) ancestries. The cross-ancestry meta-analysis identified 932 RE-associated variants,...
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