Article
Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping.
PLoS genetics - 1 Oct 2008
Andrew Toby, Maniatis Nikolas, Carbonaro Francis, Liew S H Melissa, Lau Winston, Spector Tim D, Hammond Christopher J
Abstract excerpt
Refractive error is a highly heritable quantitative trait responsible for considerable morbidity. Following an initial genome-wide linkage study using microsatellite markers, we confirmed evidence for linkage to chromosome 3q26 and then conducted fine-scale association mapping using high-resolution linkage disequilibrium unit (LDU) maps. We used a preliminary discovery marker set across the 30-Mb region with an...
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