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Article

Cross-trait genomic and sequential analyses of multiple omics datasets identified shared genetic components for the gut-eye axis.

Human genomics - 17 Mar 2026

Gao Yuelan, Xu Jianming, Yu Jun, Wang Yuyao, Zhang Yuzhou, Kam Ka Wai, Ho Mary, Young Alvin L, Pang Chi Pui, Tham Clement C, Yam Jason C, Chen Li Jia

Abstract excerpt

BACKGROUND: The gut–eye axis (GEA) has been proposed as a framework for understanding comorbidity between gastrointestinal and ocular diseases. This study aimed to investigate their shared genetic architecture, pleiotropy, and putative biological pathways potentially influenced by environmental exposures and gut microbiota. METHODS: This study integrated large-scale genome-wide association study summary data on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41845536
DOI: 10.1186/s40246-026-00947-6
PMCID: PMC13107603

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RBFOX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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