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Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking

23 Aug 2025

Abstract excerpt

Strabismus is a common pediatric eye misalignment and has complex genetic and environmental causes. Previous genome-wide association studies (GWAS) encountered difficulties in identifying strabismus risk variants due to heterogeneity and small samples. We performed large meta-analyses of 11 European-ancestry GWAS (7 sources), analysing broad strabismus (20,464 cases, 954,921 controls) and subtypes...

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PMID: 40849414
DOI: 10.1038/s41467-025-62456-9

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