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Article

CPNE1: A novel therapeutic target for myopia progression - from genetic GWAS discovery to functional validation in vitro and vivo.

Journal of translational medicine - 26 Mar 2026

Jia Lanbo, Wei Pinghui, Wang Yining, Xia Zitian, Gao Shan, Wang Yan, Han Guoge

Abstract excerpt

BACKGROUND: Myopia, a complex condition influenced by genetic and environmental factors, is an increasing global health concern, and its underlying mechanisms remain unclear. Genome-wide association studies (GWAS) meta combined with summary-data-based Mendelian randomization (SMR) is a robust tool to identify novel regulatory genes associated with myopia. METHODS: We performed a fixed-effect meta-analysis of two...

Topics

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Disease Progression
Gene Expression Regulation
Genetic Predisposition to Disease
Genome-Wide Association Study
Myopia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Reproducibility of Results

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Open in PubMed Open full text

Identifiers

PMID: 41888893
DOI: 10.1186/s12967-026-08050-z
PMCID: PMC13141628

Genes

CPNE1
COL1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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