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Article

Pyra-Metho-Carnil Suppresses CD73-associated Macrophage Infiltration in KRAS-mutant Colorectal Cancer.

Anticancer research - 1 Aug 2026

Kitaguchi Takanori, Abe Seimon, Matsumoto Taichi, Yoshida Kazumasa, Maruta Gen, Maeoka Hisanori, Ishikura Shuhei, Ishida Yusuke, Hirai Fumihito, Aoki Mikiko, Hamada Toshihiro, Nakabayashi Kazuhiko, Koikawa Kazuhiro, Nakano Michitaka, Shirasawa Senji, Tsunoda Toshiyuki

Abstract excerpt

BACKGROUND/AIM: We previously reported that Pyra-Metho-Carnil (PMC) suppresses macrophage differentiation in co-culture with mutant (mt) Kirsten rat sarcoma (KRAS) tumors. In this study, we used integrative proteomics and identified a KRAS-regulated membrane and exosomal protein, 5'-nucleotidase ecto (NT5E)/CD73, as a key candidate linking KRAS signaling to macrophage-associated tumor immune microenvironment...

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Identifiers

PMID: 42527098
DOI: 10.21873/anticanres.18322

Genes

KRAS
CD68
NT5E

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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