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Article

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Nature communications - 22 Feb 2018

Cooks Tomer, Pateras Ioannis S, Jenkins Lisa M, Patel Keval M, Robles Ana I, Morris James, Forshew Tim, Appella Ettore, Gorgoulis Vassilis G, Harris Curtis C

Abstract excerpt

TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOFs) distinct from the tumor suppressor activity of the wild-type protein. Tumor-associated macrophages (TAMs), a hallmark of solid tumors, are typically correlated with poor prognosis. Here, we report a non-cell-autonomous mechanism, whereby human mutp53 cancer cells reprogram...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29472616
DOI: 10.1038/s41467-018-03224-w
PMCID: PMC5823939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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