Article
Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer.
Signal transduction and targeted therapy - 9 Apr 2021
Liu Huashan, Liang Zhenxing, Zhou Chi, Zeng Ziwei, Wang Fengwei, Hu Tuo, He Xiaowen, Wu Xiaojian, Wu Xianrui, Lan Ping
Abstract excerpt
Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell-extrinsic role of KRAS, where KRAS engages with the tumor microenvironment by functional reprogramming of tumor-associated macrophages (TAMs). In human CRC specimens, mutant KRAS positively correlates with the presence of TAMs....
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