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Photo-switchable CRISPR electrochemical system enables de-interferential biosensing signal output.

Biosensors & bioelectronics - 15 Nov 2026

Zhao Junhong, He Jinghang, Du Huanyu, Dai Changhao, Ma Xinye, Kong Derong, Yue Yang, Zhang Shen, Liu Kaiwen, Liu Yunqi, Zhang Guanghui, Wu Yungen, Wei Dacheng

Abstract excerpt

Most clustered regularly interspaced short palindromic repeats (CRISPR)-based electrochemical biosensors lack controllable switching function and are vulnerable to false signals induced by intrinsic amplification signal crosstalk. Thus, exploring strategies that mitigate intrinsic amplification crosstalk with a precise switch would be extremely useful for reliable and accurate bioanalysis. Herein, we develop a...

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PMID: 42526210
DOI: 10.1016/j.bios.2026.119067

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PC

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