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Article

One-base-mismatch CRISPR-based transistors for single nucleotide resolution assay.

Biosensors & bioelectronics - 15 Oct 2024

Ma Hongwenjie, Tian Yicheng, Kong Derong, Guo Mingquan, Dai Changhao, Wang Qiang, Li Shenwei, Tian Zhengan, Liu Yunqi, Wei Dacheng

Abstract excerpt

An effective strategy for accurately detecting single nucleotide variants (SNVs) is of great significance for genetic research and diagnostics. However, strict amplification conditions, complex experimental instruments, and specialized personnel are required to obtain a satisfactory tradeoff between sensitivity and selectivity for SNV discrimination. In this study, we present a CRISPR-based transistor biosensor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38986250
DOI: 10.1016/j.bios.2024.116548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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