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CRISPR-Cas12a Biosensor Array for Ultrasensitive Detection of Unamplified DNA with Single-Nucleotide Polymorphic Discrimination.

ACS sensors - 28 Apr 2023

Weng Zhengyan, You Zheng, Li Huijie, Wu Guangfu, Song Yang, Sun He, Fradlin Ava, Neal-Harris Camille, Lin Mengshi, Gao Xue, Zhang Yi

Abstract excerpt

Quantitative polymerase chain reaction as a powerful tool for DNA detection has been pivotal to a vast range of applications, including disease screening, food safety assessment, environmental monitoring, and many others. However, the essential target amplification step in combination with fluorescence readout poses a significant challenge to rapid and streamlined analysis. The discovery and engineering of the...

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PMID: 37027291
DOI: 10.1021/acssensors.2c02495

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