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Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution

15 Jun 2023

Abstract excerpt

Nematode excretory-secretory (ES) products are essential for the establishment and maintenance of infections in mammals and are valued as therapeutic and diagnostic targets. While parasite effector proteins contribute to host immune evasion and anthelmintics have been shown to modulate secretory behaviors, little is known about the cellular origins of ES products or the tissue distributions of drug targets. We...

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PMID: 37318129
DOI: 10.7554/elife.83100

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