Article
Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites.
Molecular & cellular proteomics : MCP - 1 Oct 2014
Armstrong Stuart D, Babayan Simon A, Lhermitte-Vallarino Nathaly, Gray Nick, Xia Dong, Martin Coralie, Kumar Sujai, Taylor David W, Blaxter Mark L, Wastling Jonathan M, Makepeace Benjamin L
Abstract excerpt
Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of ∼6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No vaccine exists for the major filarial diseases, lymphatic filariasis and onchocerciasis; in part because research on protective immunity against filariae has been...
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