Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi

7 Apr 2022

Abstract excerpt

Lymphatic filariasis (LF) is a chronic debilitating neglected tropical disease (NTD) caused by mosquito-transmitted nematodes that afflicts over 60 million people. Control of LF relies on routine mass drug administration with antiparasitics that clear circulating larval parasites but are ineffective against adults. The development of effective adulticides is hampered by a poor understanding of the processes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Insect symbiosis and bacterial influences
Share to Parasitic Diseases Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35390105
DOI: 10.1371/journal.ppat.1010399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayiPMID 35390105Read ↗

Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite <i>Brugia malayi</i>Semantic proximity Read ↗

Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayiSemantic proximity Read ↗

Miniature spatial transcriptomics for studying parasite-endosymbiont relationships at the micro scaleSemantic proximity Read ↗

The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis.Semantic proximity Read ↗

Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolutionSemantic proximity Read ↗

Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolutionSemantic proximity Read ↗

A Deep Sequencing Approach to Comparatively Analyze the Transcriptome of Lifecycle Stages of the Filarial Worm, Brugia malayiSemantic proximity Read ↗

Genetic and functional diversification of chemosensory pathway receptors in mosquito-borne filarial nematodes.Semantic proximity Read ↗

Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune functionSemantic proximity Read ↗

Extracellular vesicles secreted by <i>Brugia malayi</i> microfilariae modulate the melanization pathway in the mosquito hostSemantic proximity Read ↗

Dual RNA-seq of Parasite and Host Reveals Gene Expression Dynamics during Filarial Worm–Mosquito InteractionsSemantic proximity Read ↗

Immunological genomics of <i>Brugia malayi</i>: filarial genes implicated in immune evasion and protective immunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.