Article
Non-Canonical Binding of Nelfinavir in HIV-1 Protease Variants Reveals Structural Mechanisms of Antiretroviral Resistance.
Viruses - 25 Jun 2026
Cadena-Cruz Christian, De Avila-Arias Marcio, Guzmán Fabio, Pérez Mariana, Zuluaga María Angelica, Navarro Quiroz Elkin, Angulo Alejandro, Garcerant Luz Elena Prieto, Rojas Hector Rodríguez, Chica Dinno Alberto Fernández, Cervantes Guillermo, Villarreal-Camacho Jose Luis
Abstract excerpt
BACKGROUND: Antiretroviral resistance-associated mutations, within the broader context of HIV-1 genetic variability, represent a growing challenge for HIV-1 control, highlighting the need for continuous molecular surveillance and mechanistic understanding of drug resistance. This study aimed to characterize mutations in the pol gene associated with resistance to protease inhibitors and to explore their structural...
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