Article
Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jun 2011
Alcaro Stefano, Alteri Claudia, Artese Anna, Ceccherini-Silberstein Francesca, Costa Giosuè, Ortuso Francesco, Parrotta Lucia, Perno Carlo Federico, Svicher Valentina
Abstract excerpt
In recent years relevant progress has been made in the treatment of HIV-1 with a consequent decrease in mortality. The availability of potent antiretroviral drugs and the ability of viral load assays that accurately evaluate the true level of viral replication, have led to a better understanding of pathogenesis of the disease and how to obtain improved therapeutic profiles. The highly active antiretroviral...
Topics
- Antiretroviral Therapy, Highly Active
- Crystallography, X-Ray
- Drug Resistance, Viral
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Models, Molecular
- Mutation
- Nucleosides
- Reverse Transcriptase Inhibitors
- Treatment Failure