HIV-1 Protease: Structural Perspectives on Drug Resistance

doi:10.3390/v1031110

Article

HIV-1 Protease: Structural Perspectives on Drug Resistance

3 Dec 2009

Abstract excerpt

Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design and have dramatically improved AIDS therapy. Analysis of the structures and activities of drug resistant protease variants has revealed novel molecular mechanisms of drug resistance and guided the design of tight-binding inhibitors for resistant variants. The plethora of structures reveals distinct molecular mechanisms...

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