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Article

Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.

The FEBS journal - 1 Aug 2020

Kneller Daniel W, Agniswamy Johnson, Harrison Robert W, Weber Irene T

Abstract excerpt

Drug-resistance is a serious problem for treatment of the HIV/AIDS pandemic. Potent clinical inhibitors of HIV-1 protease show several orders of magnitude worse inhibition of highly drug-resistant variants. Hence, the structure and enzyme activities were analyzed for HIV protease mutant HIV-1 protease (EC 3.4.23.16) (PR) with 22 mutations (PRS5B) from a clinical isolate that was selected by machine learning to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31920003
DOI: 10.1111/febs.15207
PMCID: PMC7343616

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