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Article

Novel Susceptibility Genes for Sepsis Revealed by a Cross-Tissue Transcriptome-Wide Association Study.

Shock (Augusta, Ga.) - 1 Apr 2026

Tao Linfeng, Zhu Ning, Zhu Yue, Li Chao, Pan Yiyuan, Chen Yan, Liu Jun

Abstract excerpt

BACKGROUND: Sepsis, a life-threatening syndrome triggered by a dysregulated host response to infection, continues to impose a substantial global health burden. Advances in genomics and transcriptomics now enable systematic exploration of sepsis pathogenesis at the genetic level. The integration of genome-wide association studies and transcriptome-wide association studies (TWAS) offers a powerful framework to...

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PDGFB gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Sepsis
Transcriptome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 40705358
DOI: 10.1097/SHK.0000000000002652
PMCID: PMC13023095

Genes

ATG4B
PDGFB
ZCCHC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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