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Predicting Disease Progression and Survival in Amyotrophic Lateral Sclerosis.

Muscle & nerve - 1 Jun 2026

Seyam Muhannad, Morelli Kathryn H, Waheed Waqar, van den Berg Leonard H, Tandan Rup

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) progresses relentlessly and is characterized by a median survival of 2-5 years from symptom onset with death from respiratory failure. ALS is a complex, multi-system neurodegenerative disorder with significant phenotypic heterogeneity and markedly variable disease progression. This variability presents challenges in determining the optimal timing for therapeutic interventions,...

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PMID: 41866924
DOI: 10.1002/mus.70198

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