Article

Serum Troponin T levels as a therapy response marker in SOD1-mediated ALS

2025-02-17

Abstract excerpt

<h4>Introduction</h4> Serum cardiac troponin T (cTnT) levels are elevated in the majority of amyotrophic lateral sclerosis (ALS) patients and increase over time. Neurofilament light chain (NfL) is an established therapy response biomarker in ALS as superoxide dismutase 1 (SOD1)-ALS patients treated with the antisense oligonucleotide tofersen show a decrease in NfL. In this study we assess the course of cTnT levels...

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Literature Corpus work: 963a3eaa-9cac-5499-aaf6-564a3d407cba
DOI: 10.1101/2025.02.13.25322198

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