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Phenome-wide association study in 25,639 pregnant Chinese women reveals loci associated with maternal comorbidities and child health.

Cell genomics - 9 Oct 2024

Guo Jintao, Guo Qiwei, Zhong Taoling, Xu Chaoqun, Xia Zhongmin, Fang Hongkun, Chen Qinwei, Zhou Ying, Xie Jieqiong, Jin Dandan, Yang You, Wu Xin, Zhu Huanhuan, Hour Ailing, Jin Xin, Zhou Yulin, Li Qiyuan

Abstract excerpt

Phenome-wide association studies (PheWAS) have been less focused on maternal diseases and maternal-newborn comorbidities, especially in the Chinese population. To enhance our understanding of the genetic basis of these related diseases, we conducted a PheWAS on 25,639 pregnant women and 14,151 newborns in the Chinese Han population using ultra-low-coverage whole-genome sequence (ulcWGS). We identified 2,883...

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Identifiers

PMID: 39389020
DOI: 10.1016/j.xgen.2024.100632
PMCID: PMC11602594

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