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Article

Genetic survey of biomarkers at early and mid-pregnancy identifies pregnancy-specialized immune regulation.

PLoS genetics - 1 Jun 2026

Cakir Merve, Traglia Michela, Alexeeff Stacey, Ames Jennifer L, Ashwood Paul, Grosvenor Luke P, Gunderson Erica P, Kim Danielle H J, Liang Jane W, Qian Yinge, Sahagun Elizabeth, Yolken Robert, Van de Water Judy, Croen Lisa A, Weiss Lauren A

Abstract excerpt

Much remains unknown about the genetics of immune system changes during pregnancy. We used SNP data in a pregnancy cohort to genetically investigate 47 immune biomarkers at two timepoints, along with change between timepoints (Δ). We identified 19 biomarkers with significant SNP-based heritability and 34 with genome-wide significant signals, demonstrating genetic regulation. The same biomarkers measured in early-...

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PMID: 42378311
DOI: 10.1371/journal.pgen.1012204
PMCID: PMC13340790

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