Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics.

doi:10.1038/s41598-026-61834-7

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Article

Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics.

Scientific reports - 27 Jul 2026

Hesse Julia, Resch Ulrike, Görtz Lotte, Lang Sarah, Batool Roya, Saradar Sarah, Schoof Patricia, Gehlweiler Kevin, Zouikova Daniela, Jashnieh Pandora, Fernandes Velosa Ricardo, Hotzel-Hacker Nino, Suzuki Fumitaka, Bayraktar Samet, Cappallo Melanie, Schmidt Vera, Ebbert Lara, Bülow Margret H, Kucharowski Nicole, Laakkonen Eija K, Krüger Marcus, Sengle Gerhard, Chadt Alexandra, Lichtenberg Artur, Aubin Hug, Weber Elvira

Abstract excerpt

Vascular smooth muscle cells (VSMCs) are regulators of vascular homeostasis and play a role in cardiovascular diseases, including atherosclerosis and aortic aneurysms. Together with endothelial cells (ECs), they control vascular remodeling by producing extracellular matrix (ECM), regulating the expression of adhesion molecules, and releasing signaling factors. Since changes in the ECM composition critically...

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PMID: 42509278
DOI: 10.1038/s41598-026-61834-7
PMCID: PMC13408885

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