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Article

Imaging-mediated genetic effects link brain microstructure, metabolic profiles, and regional transcription to glioma susceptibility.

Frontiers in immunology - 1 Jan 2026

Wu Yufan, Wang Xuezhen, Wang Xinkai, Chen Lin, Huang Shiqi, Zhang Mingwei, Hong Jinsheng

Abstract excerpt

Background: This study aimed to systematically characterize genetically links and Mediation mechanism between glioma susceptibility and brain microstructure, cross-compartment metabolic profiles, and region-specific gene expression, followed by functional validation. Methods: Using GWAS data from 12,488 glioma cases and 18,169 controls, we performed two-sample MR (TSMR) and summary data-based MR (SMR) analyses....

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Identifiers

PMID: 42491350
DOI: 10.3389/fimmu.2026.1870121
PMCID: PMC13376868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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