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Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

28 Sept 2023

Abstract excerpt

Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular and multi-parametric magnetic resonance imaging (MRI) profiling across 313 multi-regional tumor biopsies, including 111 from the NE, across 68 HGG patients. Whole exome and...

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PMID: 37770427
DOI: 10.1038/s41467-023-41559-1

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