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Article

Cerebrospinal fluid metabolites and brain imaging in epilepsy subtypes: Mendelian randomization and multi-omics analysis.

European journal of pharmacology - 15 Jul 2026

Sun Huaiyu, Li Xuewei, Zhao Weixuan, Meng Hongmei, Zhang Wuqiong

Abstract excerpt

BACKGROUND: Epilepsy is a complex neurological disorder significantly influenced by genetic factors. Observational studies can identify associations, but cannot establish causality. Mendelian randomization (MR) offers a robust tool for identifying etiology. Therefore, using multi-omics, we explored genetically proxied associations among cerebrospinal fluid metabolites, neuroimaging phenotypes, and epilepsy to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42361880
DOI: 10.1016/j.ejphar.2026.179095

Genes

DAB1
ITGA8
RORA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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