Article
Prognostic Relevance of Surgical Margins According to KRAS and BRAF Status in Colorectal Liver Metastases: BRAF-KRAS LiverMet Collaborative Group.
Annals of surgical oncology - 1 Oct 2026
Ferrari C, Molina V, D'Ambrosio G M, Famularo S, Milana F, Patrone R, Russolillo N, Alaimo L, Roldán-Ortiz I, Nocchi N, Wassmer C, De la Serna S, Mocchegiani F, Bitto S, Garancini M, Romano F, Abreu de Carvalho L F, Berrevoet F, Nasto R A, Fallani G, Serenari M, Delvecchio A, Valle V, Halloum M, Giulianotti P, Memeo R, Cescon M, Troisi R, De Winter K, Ciulli C, Tarchi P, Vivarelli M, García Botella A, Toso C, Taddei A, Serradilla-Martín M, Ruzzenente A, Ferrero A, Izzo F, Torzilli G, Sánchez Cabús S
Abstract excerpt
BACKGROUND: Hepatic resection combined with systemic therapy represents the standard of care for colorectal liver metastases (CRLMs). Although parenchyma-sparing surgery prioritizes R0 resection and preserves liver function, the clinical relevance of minimal margins remains debated. At the same time, tumor biology, particularly KRAS and BRAF mutations, has emerged as a key determinant of outcomes. This study...
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- Aged
- Female
- Humans