Article
KRAS Mutation Status Dictates Optimal Surgical Margin Width in Patients Undergoing Resection of Colorectal Liver Metastases.
Annals of surgical oncology - 1 Jan 2017
Margonis Georgios A, Sasaki Kazunari, Andreatos Nikolaos, Kim Yuhree, Merath Katiuscha, Wagner Doris, Wilson Ana, Buettner Stefan, Amini Neda, Antoniou Efstathios, Pawlik Timothy M
Abstract excerpt
BACKGROUND: The optimal tumor-free margin width remains controversial and may be inappropriate to investigate without considering differences in the underlying tumor biology. METHODS: R1 resection was defined as margin clearance less than 1 mm. R0 resection was further divided into 3 groups: 1-4, 5-9, and ≥10 mm. The impact of margin width on overall survival (OS) relative to KRAS status [wild type (wtKRAS) vs....
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