Article
The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches.
Oncology research - 1 Jan 2024
Roncato Rossana, Polesel Jerry, Tosi Federica, Peruzzi Elena, Brugugnoli Erika, Pantano Claudia Lauria, Furfaro Maria, Girolamo Filippo DI, Nani Alessandro, Pani Arianna, Milan Noemi, DE Mattia Elena, Sartore-Bianchi Andrea, Cecchin Erika
Abstract excerpt
Objectives: Treatment of metastatic colorectal cancer (mCRC) includes resection of liver metastases (LM), however, no validated biomarker identifies patients most likely to benefit from this procedure. This meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC (i.e., RAS, BRAF, SMAD4, PIK3CA) as prognostic markers of survival and disease recurrence in...
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