Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis.

Critical reviews in oncology/hematology - 1 Mar 2016

Passiglia Francesco, Bronte Giuseppe, Bazan Viviana, Galvano Antonio, Vincenzi Bruno, Russo Antonio

Abstract excerpt

BACKGROUND: Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of CRC-related liver metastases (CLM), showing conflicting results. This meta-analysis aims to review all the studies reporting survival outcomes (recurrence free survival (RFS), and/or overall survival (OS)) of patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatectomy

Share to Liver Neoplasms

Share to Prognosis

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to Survival Rate

Source

Identifiers

PMID: 26775732
DOI: 10.1016/j.critrevonc.2015.12.015

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis.PMID 26775732Read ↗

Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

BRAF mutations and survival with surgery for colorectal liver metastases: A systematic review and meta-analysis.Semantic proximity Read ↗

Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases.Semantic proximity Read ↗

Impact of BRAF mutations on clinical outcomes following liver surgery for colorectal liver metastases: An updated meta-analysis.Semantic proximity Read ↗

The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches.Semantic proximity Read ↗

Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence.Semantic proximity Read ↗

Reevaluating the prognostic value of RAS mutation status in patients with resected liver metastases from colorectal cancer: A systematic review and meta-analysis.Semantic proximity Read ↗

A critical appraisal of the current landscape of resectable BRAF mutated colorectal liver metastases: a systematic review.Semantic proximity Read ↗

Reevaluating the prognostic role of BRAF mutation in colorectal cancer liver metastases.Semantic proximity Read ↗

BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection.Semantic proximity Read ↗

Prognostic factors of BRAF V600E colorectal cancer with liver metastases: a retrospective multicentric study.Semantic proximity Read ↗

Prognostic Role of BRAF Mutations in Colorectal Cancer Liver Metastases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.