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DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes

3 Oct 2017

Abstract excerpt

Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue...

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PMID: 29026446
DOI: 10.1186/s13148-017-0399-2

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