Article
DNA methylation in metabolic disorders.
The American journal of clinical nutrition - 1 Apr 2011
Barres Romain, Zierath Juleen R
Abstract excerpt
DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which...
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