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Article

Precision prime editing of TP53 mutations for functional tumor suppression in colorectal cancer.

Biochemical and biophysical research communications - 17 Sept 2026

Azhar Md, Malviya Rishabha, Chandra Phool, Sridhar Sathvik Belagodu, Shareef Javedh, Wadhwa Tarun

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a major global health concern, with high mortality due to genetic heterogeneity and resistance to treatment. Tumor Protein p53 (TP53) mutations are also among the most important molecular changes that can disrupt genomic stability and facilitate tumor progression, so it is a critical target for precision-based interventions. AIM: This review aims to discuss the future...

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Colorectal Neoplasms
CRISPR-Cas Systems
Gene Editing
TP53 gene
Genetic Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

Tumor Suppressor Protein p53

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Identifiers

PMID: 42470832
DOI: 10.1016/j.bbrc.2026.154311

Genes

TP53

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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