Article
Reverting TP53 Mutation in Breast Cancer Cells: Prime Editing Workflow and Technical Considerations.
Cells - 11 May 2022
Abuhamad Asmaa Y, Mohamad Zamberi Nurul Nadia, Sheen Ling, Naes Safaa M, Mohd Yusuf Siti Nur Hasanah, Ahmad Tajudin Asilah, Mohtar M Aiman, Amir Hamzah Amir Syahir, Syafruddin Saiful Effendi
Abstract excerpt
Breast cancer is the leading cause of cancer-related deaths in women. The aggressive breast cancer subtype is commonly linked to the genetic alterations in the TP53 tumor suppressor gene, predominantly the missense mutations. Robust experimental models are needed to gain better insights into these mutations’ molecular properties and implications in tumorigenesis. The generation of such models harboring the...
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