Article
The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.
Cellular & molecular immunology - 1 Sept 2026
Hurley Kate, Kaul Rachel, Yadav Sahil, Rijal Dikchha, Sam Leila, Bhan Avni, Hamra Rayan El, Ariana Ardeshir, Mahdi Adam, Brandt Willem, Tomlinson Julianna J, Schlossmacher Michael G, Sad Subash
Abstract excerpt
Allelic variants in the leucine-rich repeat kinase-2 (LRRK2) gene are linked to Parkinson's disease, Crohn's disease and leprosy; however, a consensus role of LRRK2 in infection has not yet emerged. Parkinson's disease-linked p.G2019S mutation of LRRK2 results in increased kinase activity. We evaluated the impact of the p.G2019S mutation during the infection of mice with Salmonella typhimurium (ST) or Listeria...
Read the complete abstract on PubMedTopics
- Animals
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Neutrophils
- NADPH Oxidase 2
- Mutation