T253X Mutations Alter Local Structure and Trigger Tyr236 Hydration in p53 DNA-Binding Domain.

doi:10.1021/acs.jpcb.6c01875

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Article

T253X Mutations Alter Local Structure and Trigger Tyr236 Hydration in p53 DNA-Binding Domain.

The journal of physical chemistry. B - 30 Jul 2026

Imam Ibrahim A, Holcomb Nathaniel C, Ellingson Sally, D'Orazio John, Shao Qing

Abstract excerpt

Mutations in the DNA-binding domain (DBD) of the p53 tumor suppressor are common in human cancers and frequently compromise its structural integrity or DNA-binding activity. Threonine 253 (Thr253) lies within the S9 aggregation-prone region, and multiple clinically reported substitutions at this position have been observed in patients with inherited cancer predisposition. However, the structural consequences of...

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PMID: 42460888
DOI: 10.1021/acs.jpcb.6c01875

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