Olfactomedin 2 Promotes Atherosclerosis by Eliciting Smooth Muscle Foam Cell Formation.

doi:10.1161/ATVBAHA.125.323448

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Olfactomedin 2 Promotes Atherosclerosis by Eliciting Smooth Muscle Foam Cell Formation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2026

Shi Ning, Cai Dunpeng, Chandrasekar Bysani, Higashi Yusuke, Chen Shi-You

Abstract excerpt

BACKGROUND: Atherosclerosis is a chronic vascular disease with a complex pathophysiology involving smooth muscle cell (SMC) dysfunction, and Olfm2 (olfactomedin 2) plays a role in SMC phenotype modulation. However, it is unclear if Olfm2 is involved in the development of atherosclerosis. METHODS: Olfm2 global and SMC-specific knockout models were used to study its role in the development of atherosclerosis....

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Aorta
Aortic Diseases
Diet, High-Fat
Foam Cells
Lipoproteins, LDL
Mice, Knockout, ApoE
Myocytes, Smooth Muscle

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Plaque, Atherosclerotic

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Identifiers

PMID: 42460474
DOI: 10.1161/ATVBAHA.125.323448
PMCID: PMC13378437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.