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Article

IL-1 polymorphisms modulates functional recovery following rehabilitation in multiple sclerosis.

Frontiers in immunology - 1 Jan 2026

Agliardi Cristina, Guerini Franca Rosa, Zanzottera Milena, Bolognesi Elisabetta, Caputo Domenico, Groppo Elisabetta, Rovaris Marco, Clerici Mario

Abstract excerpt

Background: Interleukin-1 (IL-1) cytokines as well as IL-1 genes are key regulators of neuroinflammation in Multiple Sclerosis (MS), with emerging roles in synaptic plasticity and tissue repair. While genetic determinants of MS susceptibility have been extensively characterized, their contribution to neurofunctional recovery remains poorly understood. Objective: To investigate whether functional polymorphisms in...

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Alleles
Genetic Predisposition to Disease
Interleukin-1
Interleukin-1alpha
Interleukin-1beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiple Sclerosis

Polymorphism, Single Nucleotide

Recovery of Function

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Identifiers

PMID: 42454040
DOI: 10.3389/fimmu.2026.1872267
PMCID: PMC13364626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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