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TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.

Neurology - 28 May 2013

Comabella Manuel, Caminero Ana B, Malhotra Sunny, Agulló Luis, Fernández Oscar, Reverter Ferran, Vandenbroeck Koen, Rodríguez-Antigüedad Alfredo, Matesanz Fuencisla, Izquierdo Guillermo, Urcelay Elena, López-Larios Arturo, Sánchez Alex, Otero Susana, Tintoré Mar, Montalban Xavier

Abstract excerpt

OBJECTIVES: To investigate the roles of 2 polymorphisms of the tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) gene, rs1800693 (a common variant) and rs4149584 (a coding polymorphism that results in an amino acid substitution-R92Q), as genetic modifiers of multiple sclerosis (MS), and to evaluate their potential functional implications in the disease. METHODS: The effects of rs1800693 and...

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Share to Age Factors
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Share to Polymorphism, Genetic
Share to Receptors, Tumor Necrosis Factor, Type I
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PMID: 23624563
DOI: 10.1212/WNL.0b013e318294b2d6

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TNF

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