Interleukin 6 SNP rs1818879 Regulates Radiological and Inflammatory Activity in Multiple Sclerosis.

doi:10.3390/genes13050897

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Article

Interleukin 6 SNP rs1818879 Regulates Radiological and Inflammatory Activity in Multiple Sclerosis.

Genes - 17 May 2022

Bruno Antonio, Dolcetti Ettore, Azzolini Federica, Moscatelli Alessandro, Gambardella Stefano, Ferese Rosangela, Rizzo Francesca Romana, Gilio Luana, Iezzi Ennio, Galifi Giovanni, Borrelli Angela, Buttari Fabio, Furlan Roberto, Finardi Annamaria, De Vito Francesca, Musella Alessandra, Guadalupi Livia, Mandolesi Georgia, Centonze Diego, Stampanoni Bassi Mario

Abstract excerpt

(1) Background: The clinical course of multiple sclerosis (MS) is critically influenced by the expression of different pro-inflammatory and anti-inflammatory cytokines. Interleukin 6 (IL-6) represents a major inflammatory molecule previously associated with exacerbated disease activity in relapsing remitting MS (RR-MS); however, the role of single-nucleotide polymorphisms (SNPs) in the IL-6 gene has not been...

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PMID: 35627281
DOI: 10.3390/genes13050897
PMCID: PMC9141517

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