Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.

doi:10.1212/01.wnl.0000436612.66328.8a

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Article

Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.

Neurology - 26 Nov 2013

Ottoboni Linda, Frohlich Irene Y, Lee Michelle, Healy Brian C, Keenan Brendan T, Xia Zongqi, Chitnis Tanuja, Guttmann Charles R, Khoury Samia J, Weiner Howard L, Hafler David A, De Jager Philip L

Abstract excerpt

OBJECTIVE: We set out to characterize the clinical impact and functional consequences of rs1800693(G), the multiple sclerosis (MS) susceptibility allele found in the TNFRSF1A locus. METHODS: We analyzed prospectively collected data on patients with MS to assess the role of the TNFRSF1A locus on disease course and treatment response. Using archival serum samples and freshly isolated monocytes from patients with MS...

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PMID: 24174586
DOI: 10.1212/01.wnl.0000436612.66328.8a
PMCID: PMC3843384

Genes

TNF
CXCL10
RGS1
TAGAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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