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Article

The Variant rs7665090 Is Associated With Interferon-Beta Response in Multiple Sclerosis Patients.

European journal of neurology - 1 Jul 2025

Vilaseca Andreu, Urcelay Elena, Malhotra Sunny, Castillo Mireia, Aroca Montserrat, Vidal-Jordana Angela, Pappolla Agustín, Carvajal René, Arrambide Georgina, González-Jiménez Adela, Gómez-Delgado Irene, Cobo-Calvo Alvaro, Mongay-Ochoa Neus, Rodriguez-Acevedo Breogan, Tur Carmen, Villacieros-Álvarez Javier, Ariño Helena, Castilló Joaquín, Zabalza Ana, Midaglia Luciana, La Puma Delon, Sastre-Garriga Jaume, Tintoré Mar, Río Jordi, Montalban Xavier, Comabella Manuel

Abstract excerpt

BACKGROUND: GG homozygosity for the risk gene variant rs7665090 has been reported to enhance nuclear factor kappa B (NFκB) activity in T cells from multiple sclerosis (MS) patients. Here, we investigated the association between this polymorphism and the response to different disease-modifying therapies in MS. METHODS: The rs7665090 polymorphism was genotyped in 558 MS patients treated with injectable therapies...

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Identifiers

PMID: 40665510
DOI: 10.1111/ene.70227
PMCID: PMC12263501

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