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Article

Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.

Molecular psychiatry - 1 Aug 2008

Wong M-L, Dong C, Maestre-Mesa J, Licinio J

Abstract excerpt

There are clinical parallels between the nature and course of depressive symptoms in major depressive disorder (MDD) and those of inflammatory disorders. However, the characterization of a possible immune system dysregulation in MDD has been challenging. Emerging data support the role of T-cell dysfunction. Here we report the association of MDD and antidepressant response to genes important in the modulation of...

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Identifiers

PMID: 18504423
DOI: 10.1038/mp.2008.59
PMCID: PMC2650233

Genes

CXCL10
PRKCH
PSMB4
PSMD9
STAT3
TBX21
UCN3

Provenance

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