Article
Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder.
Cellular and molecular neurobiology - 1 Aug 2020
Bialek Katarzyna, Czarny Piotr, Watala Cezary, Synowiec Ewelina, Wigner Paulina, Bijak Michal, Talarowska Monika, Galecki Piotr, Szemraj Janusz, Sliwinski Tomasz
Abstract excerpt
The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α, IL-1β, and TNF-α is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C-IL-1β (rs1143623), c. -118 C > T-IL-1β (rs1143627), c.340G > T-IL-1α (rs17561), c.-1211T > C-TNF-α (rs1799964) and c.-488G > A-TNF-α (rs1800629). These were analyzed using TaqMan...