Article
Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2003
Yu Younger W-Y, Chen Tai-Jui, Hong Chen-Jee, Chen Hung-Mei, Tsai Shih-Jen
Abstract excerpt
Proinflammatory cytokines, including interleukin (IL)-1beta, are suggested to have a role in the pathogenesis of major depressive disorder (MDD) and be related to the therapeutic effects of antidepressants. To elucidate a genetic predisposition of MDD, we studied biallelic polymorphism in the promoter region (position -511) of the IL-1beta gene in 157 patients with MDD and in 112 controls. We also examined the...
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