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Article

Clinical Significance of FLT3-ITD Variation Allele Frequency in Acute Myeloid Leukemia: A Multicenter Study.

Hematological oncology - 1 Jul 2026

Guo Laibing, Song Jingyan, Zang Haoyu, Cao Yang, Lin Yan, Zheng Zhuojun, Chen Suning, Wen Lijun, Miao Yuqing, Gu Weiying

Abstract excerpt

The specific prognostic impact of FLT3-ITD variant allele frequency (VAF) in acute myeloid leukemia (AML) remains unclear. In this multi-center study of 190 AML patients harboring FLT3-ITD mutations, a VAF cut-off of 40% was applied. Patients with high VAF (≥ 40%) exhibited significantly higher white blood cell counts, lactate dehydrogenase levels, and bone marrow blast percentages, alongside markedly shorter...

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Identifiers

PMID: 42446166
DOI: 10.1002/hon.70218
PMCID: PMC13367014

Genes

FLT3
DNMT3A
NPM1

Provenance

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