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Article

Clinical Significance of FLT3-ITD Variation Allele Frequency in Acute Myeloid Leukemia: A Multicenter Study.

Hematological oncology - 1 Jul 2026

Guo Laibing, Song Jingyan, Zang Haoyu, Cao Yang, Lin Yan, Zheng Zhuojun, Chen Suning, Wen Lijun, Miao Yuqing, Gu Weiying

Abstract excerpt

The specific prognostic impact of FLT3-ITD variant allele frequency (VAF) in acute myeloid leukemia (AML) remains unclear. In this multi-center study of 190 AML patients harboring FLT3-ITD mutations, a VAF cut-off of 40% was applied. Patients with high VAF (≥ 40%) exhibited significantly higher white blood cell counts, lactate dehydrogenase levels, and bone marrow blast percentages, alongside markedly shorter...

Topics

Humans
fms-Like Tyrosine Kinase 3
Leukemia, Myeloid, Acute
Nucleophosmin
Female
Gene Frequency
Prognosis
Male
Mutation
Middle Aged
Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Aged

DNA Methyltransferase 3A

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42446166
DOI: 10.1002/hon.70218
PMCID: PMC13367014

Genes

FLT3
DNMT3A
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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