Clinical implications of variant allele frequencies of genes in patients with acute myeloid leukemia.

doi:10.1093/oncolo/oyag099

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Article

Clinical implications of variant allele frequencies of genes in patients with acute myeloid leukemia.

The oncologist - 8 May 2026

Zhao Li, Cheng Feng, Wei Jinming, Liu Riming, Zhao Qi, Zhang Yanhong, Li Yulan

Abstract excerpt

PURPOSES: Although next-generation sequencing (NGS) has allowed for the detection of mutations in acute myeloid leukemia (AML), the clinical relevance of variant allele frequency (VAF) for the majority of mutations is unknown. This study aimed to investigate whether the VAFs of AML-associated mutations could improve the prognostic classification in AML. METHODS: Bone marrow samples from 254 AML patients were...