Article
Molecular evidence for the bi-clonal origin of neuroendocrine tumor derived metastases.
BMC genomics - 5 Nov 2012
Rinner Beate, Gallè Birgit, Trajanoski Slave, Fischer Carina, Hatz Martina, Maierhofer Theresa, Michelitsch Gabriele, Moinfar Farid, Stelzer Ingeborg, Pfragner Roswitha, Guelly Christian
Abstract excerpt
BACKGROUND: Reports on common mutations in neuroendocrine tumors (NET) are rare and clonality of NET metastases has not been investigated in this tumor entity yet. We selected one NET and the corresponding lymph node and liver metastases as well as the derivative cell lines to screen for somatic mutations in the primary NET and to track the fate of genetic changes during metastasis and in vitro progression....
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