Clinicopathologic and Molecular Analysis of Colorectal Carcinomas With Spectrum of Neuroendocrine Carcinoma Components.

doi:10.1016/j.modpat.2025.100855

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clinicopathologic and Molecular Analysis of Colorectal Carcinomas With Spectrum of Neuroendocrine Carcinoma Components.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2025

Albayrak Nazire E, Liu Bella L, Mehrotra Meenakshi, Houldsworth Jane, Polydorides Alexandros D, Ward Stephen C

Abstract excerpt

The genetics of colorectal carcinoma (CRC) with neuroendocrine differentiation remain poorly understood; recent studies focusing on pure neuroendocrine carcinomas (NECs) demonstrated mutation profiles closely resembling colorectal adenocarcinomas (ACAs) with more frequent BRAF mutations and Rb/p16 pathway dysregulation. However, pathogenesis of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) and ACAs...

Read the complete abstract on PubMed

Topics

Humans
Female
Male
Carcinoma, Neuroendocrine
Aged
Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Adenocarcinoma

Biomarkers, Tumor

Mutation

Adult

Aged, 80 and over

Proto-Oncogene Proteins B-raf

Source

Open in PubMed

Identifiers

PMID: 40738324
DOI: 10.1016/j.modpat.2025.100855

Genes

BRAF
BRCA1
RB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinicopathologic and Molecular Analysis of Colorectal Carcinomas With Spectrum of Neuroendocrine Carcinoma Components.PMID 40738324Read ↗

Comprehensive analysis of mutational and clinicopathologic characteristics of poorly differentiated colorectal neuroendocrine carcinomas.Semantic proximity Read ↗

In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.Semantic proximity Read ↗

Genetic Characteristics of Colorectal Neuroendocrine Carcinoma: More Similar to Colorectal Adenocarcinoma.Semantic proximity Read ↗

Origin and evolution of colorectal mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN).Semantic proximity Read ↗

Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas.Semantic proximity Read ↗

Genetic alterations of GI-NECs involving three main signaling pathways.Semantic proximity Read ↗

Digestive System Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.Semantic proximity Read ↗

Colorectal neuroendocrine carcinomas and adenocarcinomas share oncogenic pathways. A clinico-pathologic study of 12 cases.Semantic proximity Read ↗

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract.Semantic proximity Read ↗

Unraveling molecular pathways of poorly differentiated neuroendocrine carcinomas of the gastroenteropancreatic system: A systematic review.Semantic proximity Read ↗

Exploring Intratumoral Heterogeneity in Mixed Neuroendocrine-Nonneuroendocrine Neoplasms with Spatial Transcriptomics: Even More Diverse Than AnticipatedSemantic proximity Read ↗

Molecular-clinical characteristics and treatment outcomes in 163 metastatic colorectal neuroendocrine carcinomas with a comparison to colorectal adenocarcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.